SBI4U1 Advanced Biology|Stem Cell Therapy

SBI4U1 Advanced Biology|Stem Cell Therapy
ntroduction: Lucy is a baby girl who comes to see the pediatrician because she has been getting a lot of ear and skin infections. In this activity, you will learn about genes and protein synthesis to try to help Lucy. Vocabulary: As new vocabulary is introduced, the words are presented in the Gizmo as orange text – clicking the orange text opens the glossary page for that term. You can use the glossary at any point. 1. Lucy does not have enough white blood cells for her immune system to fight infections. Was this caused by human immunodeficiency virus (HIV) or ADA Severe Combined Immunodeficiency (ADA-SCID)? 2. Describe the cause and effects of each kind of mutation below: a. Active site mutation: b. Stop codon mutation: c. tRNA Error: 3. Answer the following questions for the experiments performed: 1 i. What was the experiment investigating? ii. What was done during the experiment? iii. What did the result prove? a. Experiment 1: b. Experiment 2: 4. Which mutation caused Lucy’s immunodeficiency disease? Explain how this mutation stopped her ADA protein from working. 5. Your scan of Lucy’s ADA gene showed a mutation in the active site. Why was this mutation not a problem? 2 6. Explain how stem cell therapy helped Lucy break down deoxyadenosintroduction: Lucy is a baby girl who comes to see the pediatrician because she has been getting a lot of ear and skin infections. In this activity, you will learn about genes and protein synthesis to try to help Lucy. Vocabulary: As new vocabulary is introduced, the words are presented in the Gizmo as orange text – clicking the orange text opens the glossary page for that term. You can use the glossary at any point. 1. Lucy does not have enough white blood cells for her immune system to fight infections. Was this caused by human immunodeficiency virus (HIV) or ADA Severe Combined Immunodeficiency (ADA-SCID)? 2. Describe the cause and effects of each kind of mutation below: a. Active site mutation: b. Stop codon mutation: c. tRNA Error: 3. Answer the following questions for the experiments performed: 1 i. What was the experiment investigating? ii. What was done during the experiment? iii. What did the result prove? a. Experiment 1: b. Experiment 2: 4. Which mutation caused Lucy’s immunodeficiency disease? Explain how this mutation stopped her ADA protein from working. 5. Your scan of Lucy’s ADA gene showed a mutation in the active site. Why was this mutation not a problem? 2 6. Explain how stem cell therapy helped Lucy break down deoxyadenosi
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